The role of Schistosoma mansoni infection in chronic non– communicable disease burden among adults in Mangochi district
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Date
2020-11-11
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Kamuzu University of Health Sciences
Abstract
Type of study: Cross sectional study. Problem to be studied: Schistosomiasis is a Neglected Tropical Disease (NTD)
caused by infection with parasitic flatworms of the
Schistosoma genus. The two species prevalent in Malawi are
Schistosoma haematobium and Schistosoma mansoni which
cause genitourinary and intestinal disease respectively. S.
haematobium is recognized as an etiological agent in the
causal pathway for cervical and bladder cancer. However, the
contribution of S. mansoni infection to the chronic non –
communicable disease burden in Malawi is not known.
Objectives: The objectives of the study are:
i. To estimate prevalence of urinary and intestinal
schistosomiasis among adult patients aged 18 years
and above with newly diagnosed or existing NCD at
Mangochi District Hospital.
ii. To evaluate risk factors for urinary and intestinal
schistosomiasis infection in in- and outpatient adults
aged 18 years and above presenting with newly
diagnosed or existing NCDs at mangochi district
hospital.
iii. To evaluate the association between schistosomiasis
infection and NCDs in in- and outpatients presenting
with existing or newly diagnosed NCDs at Mangochi
District Hospital. Methodology: This is a cross sectional study. The study population are
adults over 18 years old who have existing or newly
diagnosed NCD. They will be identified in OPD clinics, NCD
clinics and among in – patients admitted at Mangochi
Hospital. Data will be obtained from a questionnaire and
abstracted from in – and outpatient notes using a form on
ODK. Patients will also provide urine and stool samples on the
same day which will be tested for S. mansoni. Point of care
(POC) Circulating Cathodic Antigen (CCA) tests will be used
to detect S. mansoni in urine. Microscopy using Kato – Katz
method will detect S. mansoni eggs in stool.
Expected findings and dissemination: We will describe the prevalence of S. mansoni
infection among patients with non – communicable diseases,
its risk factors in this population and association of
schistosomiasis with NCDs. We will therefore share our
findings with the University of Malawi College of Medicine,
COMREC, Mangochi District Health Office, District Health
Management Team, Communities in Mangochi, the District
Commissioner and District Executive Committee. We will also
present findings at local and international conferences and in
peer reviewed publications.