Understanding the epidemiology of iNTS disease in Africa in preparation for future iNTS
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Date
2020-10-08
Authors
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Kamuzu University of Health Sciences
Abstract
Type of study
Clinical research study involving collecting samples from human participants. Prospective serological
studies will be carried out across 4 sub-Saharan African sites (Malawi, Kenya, Burkina Faso, Ghana), for
which Malawi will be the leading site. A core protocol has been written for all 4 sites in a separate
document. This protocol focuses on the Malawi site.
Methods
to measure age-stratified acquisition of antibody and bactericidal activity to NTS. Data will be collected
on the key risk factors for invasive disease: malaria, anaemia and malnutrition and stool samples to
measure enteric NTS exposure. Children 0 to 5 years selected from mapped and censused randomly
selected households Chikwawa, Malawi; an area with substantial malaria burden - a key risk factor for
iNTS. Paired immunology and stool samples for NTS taken 3 months apart for 2000 children; distributed
over each age stratum of 1 year, from the age of 0 to 5 years (4000 samples in total).
A small number of confirmed invasive NTS cases identified at Queen Elizabeth Hospital (QECH), Blantyre,
Malawi, will also have samples for investigated for antibody and bactericidal activity at presentation and
1 month follow-up.
Other sites (Kenya, Burkina Faso, Ghana): Prospective serological community study with unpaired/
single samples taken from children aged 0-5 years. No data collected on risk factors.
Expected findings and dissemination
We will describe the pattern of immunological susceptibility to NTS and enteric exposure in relation to
risk factors and geographical settings
to facilitate early iNTS vaccine licensure. The final study report will be submitted to the College
of Medicine Research Ethics Committee (COMREC) University of Malawi, University of Liverpool IRB and
the funders (Wellcome Trust and VacciNTS project). The results will be presented locally, nationally and
internationally including other partner sites in the seroepidemiology work package of the VacciNTS
consortium contributing to key knowledge for vaccine development and deployment. This will have
relevance for policy decisions regarding iNTS control in Malawi and other sub-Saharan African countries.
Results will be submitted for publication in a peer reviewed academic journal.
Description
Keywords
Research Subject Categories::MEDICINE