Determining the normal Urea, Creatinine and Electrolytes Indices for young Malawian adults
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Date
2021-07-15
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Publisher
Kamuzu University of Health Sciences
Abstract
1.1.Type of Research
This will be a cross-sectional descriptive study aimed at establishing the normal Urea,
Creatinine and electrolytes indices for young Malawian adults in Mangochi.
1.2.The problem to be studied
Most of the medical decisions that are made by the clinicians are arrived at based on the
laboratory results. Reference indices or reference intervals act as the guiding tools for the
clinicians to make accurate interpretation of the laboratory findings. However, reference values
currently being used in most laboratories in African countries including Malawi are adopted
from the literature or the reagent inserts accompanying the reagent manuals. These indices are
derived from far more distant populations and may not actually be applicable and relevant to
Malawian population due to inherit variations such as age, gender, ethnicity and environment
including altitude and geo-chemicals among others.
1.3. Objectives
The main objective of this study is to establish normal Urea, Creatinine and electrolytes
reference indices for young Malawian adults in Mangochi. A total of 50 samples will be
collected from the Voluntary, non-remunerated blood donors at Mangochi District Hospital
who will meet the inclusion criteria. The samples will be analyzed at the College of Medicine
biochemistry laboratory and reference intervals will be established using Epi info data
management system.
1.4. Expected findings and dissemination
We expect the reference intervals of the Malawian population, Mangochi in particular to be
different from other reference intervals provided by machine inserts or those in the literature.
The results will be presented to the College faculty and a copy of the results will be submittedto the COMREC and to the COM library. We are also planning to publish the results for public
access.