Glycaemic profile of children undergoing anaesthesia (GLYCANA) at Mercy James Centre in Malawi
Loading...
Date
2021-11-11
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Kamuzu University of Health Sciences
Abstract
Type of study: This will be a cross-sectional observational study of children aged 1 day to 15
years anaesthetised at Mercy James Centre (MJC).
Problem: Hypoglycaemia and hyperglycaemia may develop during anaesthesia and surgery in
children and can lead to severe adverse clinical outcomes. However, glucose checking is not
routinely performed perioperatively in our settings. This may lead to missing children with
deranged blood sugar and related complications. No study, as far as we know, has investigated
glucose homeostasis in children undergoing surgery in Malawi.
Objective of the study: The aim of this study is to assess perioperative glucose levels of the
children undergoing anaesthesia in MJC following current anaesthesia protocols.
Methodology: Data will be collected for a minimum of 1 month. The sample will be calculated
with an online sampling tool. Paediatric patient aged from 1 day to 15 years admitted for surgery
at MJC and whose parents or legal guardians will be willing to give written consent will be
included in the study. The exclusion criteria will include neonates less than 24 hours old, children
coming for examination under anaesthesia and those whose operation will last less than 30
minutes. For each patient, socio-demographic information; pre, intra and postoperative variables
will be recorded using a designed data collection form. Anaesthesia chart will be reviewed for
data consistency. Data will be analysed using SPSS 26. ANOVA test will be used to compare
means. Chi Square test and p-values at level of significance of 5% will be calculated to establish
correlations.
Expected findings: We expect to find children with deranged glycemia preoperatively mostly
hypoglycaemia. We also expected to find children with deranged glycemia postoperatively both
hypoglycaemia and hyperglycaemia. Duration of starvation period, types of fluid perioperatively,
duration of the surgery may be the major factors associated with the variation of glycemia during
anaesthesia.
Dissemination: The findings of this study will be presented in one of the meetings at MJC, to
Queen Elizabeth Central Hospital (QECH) research committee and to College of Medicine
Research and Ethics Committee (COMREC). A manuscript will be submitted for publication in ananaesthesia pair reviewed journal.