Laboratory Based Research

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Browsing Laboratory Based Research by Subject "Burden of carbapenem resistance among urinary tract enterobacteriaceae"

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    A retrospective study on the burden of carbapenem resistance among urinary tract enterobacteriaceae isolates in Lilongwe
    (Kamuzu University of Health Sciences, 2021-01-19) Chipingu, Chifundo
    Type of Study-This is a retrospective cross-section study looking at the burden of Carbapenem resistance in Enterobacteriaceae isolated from the urinary tract of residents in Lilongwe district, central Malawi. Problem-Antimicrobial Resistance is a global challenge and Malawi being part of the global family faces similar challenges and threat to treatment of common ailments. Urinary tract infections are common in Malawi though detailed information on the extent of the burden is lacking due to poor documentation and reporting of cases, a common finding within Africa. Further to this, documentation of antimicrobial resistant patterns has been a challenge therefore calling for an effort in understanding the burden to address context and focus on root causes specific to Malawi and neighboring countries. Carbapenems have been used as last resort for treatment of Carbapenem-producing - Enterebacteriaceae. Development of resistance to this line of drugs presents a major threat for treatment of infection caused by these organisms. Globally, 44% Carbapenem resistance on gram negatives (Righi et al., 2017) has been recorded and this study will look at burden specific to Malawi. Objectives-This study will aim primarily to establish Carbapenems antimicrobial resistance burden among residents of Lilongwe, Malawi with urinary tract infection. The study will describe the burden of Enterobacteriaceae species resistance to Carbapenems from laboratory data. It will also aim to examine the relationship between the burden of UTl, demographics and clinical outcomes patients residing in Lilongwe with UTI Methodology-Retrospective urine culture and sensitivity results data for a period of six months from Partners in Hope (PIH) and National Microbiology reference laboratories will be used for this analysis. Demographic data and culture isolates data will be captured on paper based data collection forms with each sample given a unique identifier in place of patient names, electronic data in excel will also be maintained. Details of Carbapenem used will recorded for each and every isolate. Paper records and password protected electronic file will be maintained with limited access to study investigators. Expected findings and Dissemination- We estimate that the overall prevalence of Carbapenem resistance for gram negative organisms will be 44% over a period of 3 months Results for this study will be shared with Kamuzu University of Health sciences, Ministry of Health, COMREC and scientific community during conference through abstracts and presentations to inform nation for appropriate interventions.