Research & Ethics Committee

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Browsing Research & Ethics Committee by Subject "Adherence among Non-Hodgkin Lymphoma patients with concomitant ART"

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    CHOP Adherence among Aggressive Non-Hodgkin Lymphoma Patients with Concomitant ART: An Assessment of Adherence Determinants at Kamuzu Central Hospital
    (Kamuzu University of Health Sciences, 2022-04-13) Chikhambi, George
    The burden of cancer continues to grow around the world with theworld. TheWorld Health Organization (WHO) estimatesing a 47 percent increase in cases by 2040. In Malawi, the situation is also similarnot different as the with estimated age standardized mortality rates of stands at 113 per 100,000 for all types of cancers. However, Non-Hodgkin Lymphoma (NHL) is amongst the common cancers in the country contributing to over 6.5 percent of all cases of cancer in 2020 alone. The burden of NHL is even worsened by the high prevalence of HIV in the country which is at 8.9 percent. The Problem to be studied One of the critical areas for understanding in the fight against all types of cancers, in general, and specifically NHL, in particular, is adherence to treatment as evidence has shown that it has effects on optimal outcomes of cancer. Objectives Overall, the study attempts to understand the determinants of adherence to CHOP chemotherapy among all aggressive NHL cases with on concomitant antiretroviral therapy. in Lilongwe, Malawi. Specifically, the study will determine the CHOP chemotherapy adherence rate among the study population, assess the sociodemographic characteristics as well as identify quantitative health system related factors that influence CHOP adherence. Finally, spatial characteristics of the Lymphoma Cohort data will be described to appreciate the distribution of CHOP adherence. Methodology In this cohort retrospective study design, secondary data collected under the Lymphoma cohort study of the University of North Carolina project at Kamuzu Central Hospital will be used. We The study anticipate working withwill use a sample of 345 cases. Adherencewill be the outcome variable of interest. In addition, and tests of association will be carried out along with sociodemographic variables such as sex, age, and residence in the dataset. Results Dissemination Results of the study will be useful in informing efforts around on enhancing CHOP chemotherapy adherence in especially among the people living with HIV (PLHIV). The study will further and contribute to the overall goal of the National Cancer Control Strategic Plan (NCCSP) in which aims at moving toward universal health coverage andsecuring improved survival rates among NHL cases. The Rresults of the study will be shared with the Kamuzu University of Health Sciences Research and Ethics Committee (COMREC), KUHeS Library and the UNC Project in Lilongwe. Further, the results of the study will be presentedation at national dissemination conferences apart fromand publishing themed in peer reviewed journals.