Browsing by Author "Ghambi, Lughano"

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    Determinants of mortality in neonates with culture negative sepsis: Implications for antimicrobial stewardship
    (Kamuzu University of Health Sciences, 2021-09-15) Ghambi, Lughano
    Neonatal sepsis is over diagnosed and overtreated to reduce morbidity and mortality in a setting with limited diagnostics. However, this management approach also contributes to increasing rates of antimicrobial resistance (AMR). Therefore, determining the factors associated with death in neonates with culture-negative sepsis in our setting may minimize antibiotic exposure, by guiding the clinician in low resource settings to decide when to initiate and discontinue antimicrobial therapy in those most at risk for poor outcomes. This study aims to assess the factors associated with mortality among neonates with culture-negative sepsis by describing their characteristics and comparing the risk factors associated with death amongst those that died and survived. We will conduct a secondary analysis of a cross-sectional study investigating risk factors of neonatal sepsis which was conducted between May 2018 to May 2019 at Queen Elizabeth Central Hospital (QECH), Chatinkha Nursery. Rationale: Neonatal sepsis is over diagnosed and overtreated to reduce morbidity and mortality in a setting with limited diagnostics. However, this management approach also contributes to increasing rates of antimicrobial resistance (AMR). Therefore, determining the factors associated with death in neonates with culture-negative sepsis in our setting may minimize antibiotic exposure, by guiding the clinician in low resource settings to decide when to initiate and discontinue antimicrobial therapy in those most at risk for poor outcomes. Primary Objective:To assess the factors associated with mortality among culture negative sepsis neonates in a unit in Malawi. Secondary Objective: To describe the characteristics of the neonates with culture negative sepsis To compare the risk factors associated with death in neonates with culture negative sepsis neonates amongst those that died and survived Study Type: Cross-sectional study (retrospective analysis) Place of study: Queen Elizabeth Central Hospital, Chatinkha Nursery Study population: All neonates with culture negative sepsis from the primary study Sample size: All neonates with culture negative sepsis from the primary study Possible constraints: No major constraints anticipated but the data collection for the study is complete, and therefore the analysis will have to be based on the existing dataset. Dissemination: Results will disseminated through posters, oral presentation and publications