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Browsing Protocols by Author "Nyangulu, Wongani"

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    The role of Schistosoma mansoni infection in chronic non– communicable disease burden among adults in Mangochi district
    (Kamuzu University of Health Sciences, 2020-11-11) Nyangulu, Wongani
    Type of study: Cross sectional study. Problem to be studied: Schistosomiasis is a Neglected Tropical Disease (NTD) caused by infection with parasitic flatworms of the Schistosoma genus. The two species prevalent in Malawi are Schistosoma haematobium and Schistosoma mansoni which cause genitourinary and intestinal disease respectively. S. haematobium is recognized as an etiological agent in the causal pathway for cervical and bladder cancer. However, the contribution of S. mansoni infection to the chronic non – communicable disease burden in Malawi is not known. Objectives: The objectives of the study are: i. To estimate prevalence of urinary and intestinal schistosomiasis among adult patients aged 18 years and above with newly diagnosed or existing NCD at Mangochi District Hospital. ii. To evaluate risk factors for urinary and intestinal schistosomiasis infection in in- and outpatient adults aged 18 years and above presenting with newly diagnosed or existing NCDs at mangochi district hospital. iii. To evaluate the association between schistosomiasis infection and NCDs in in- and outpatients presenting with existing or newly diagnosed NCDs at Mangochi District Hospital. Methodology: This is a cross sectional study. The study population are adults over 18 years old who have existing or newly diagnosed NCD. They will be identified in OPD clinics, NCD clinics and among in – patients admitted at Mangochi Hospital. Data will be obtained from a questionnaire and abstracted from in – and outpatient notes using a form on ODK. Patients will also provide urine and stool samples on the same day which will be tested for S. mansoni. Point of care (POC) Circulating Cathodic Antigen (CCA) tests will be used to detect S. mansoni in urine. Microscopy using Kato – Katz method will detect S. mansoni eggs in stool. Expected findings and dissemination: We will describe the prevalence of S. mansoni infection among patients with non – communicable diseases, its risk factors in this population and association of schistosomiasis with NCDs. We will therefore share our findings with the University of Malawi College of Medicine, COMREC, Mangochi District Health Office, District Health Management Team, Communities in Mangochi, the District Commissioner and District Executive Committee. We will also present findings at local and international conferences and in peer reviewed publications.