Immunization

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Browsing Immunization by Author "Nkosi, Dumisile"

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    Determinants of vaccine coverage and acceptability of malaria RTSS vaccine in children aged 12-23 months in Malawi: a healthcare provider perspective, version 1.0
    (Kamuzu University of Health Sciences, 2022-07-18) Nkosi, Dumisile
    Type of research study: The study will use systematic literature review and a qualitative study design using purposive sampling of 20 healthcare workers at Zomba District Health Office. Problem statement: Developing appropriate interventions on immunization in young children requires a detailed understanding of immunisation levels and factors affecting coverage among children. Although there has been an increase in overall coverage of DPT3 from 84% to 94% between 2016 and 2020, only 78% of the 28 districts in Malawi had achieved the targeted coverage of > 80% in 2020. This indicates that there is still a gap in childhood vaccine coverage within the country. Additionally, understanding the acceptability of a vaccine before roll out helps in generating appropriate interventions to improve vaccine coverage. Therefore, this study seeks to understand the healthcare providers’ perceptions on the factors that will affect coverage and acceptability of the malaria RTSS vaccine before it is rolled out countrywide in Malawi. Objectives: The main objective of this research project is to evaluate the determinants of vaccination coverage and acceptability of the RTSS malaria vaccine in children aged 12-23 months in Malawi. The specific objectives are: to assess the determinants of vaccine coverage in children aged 12-23 months using systematic review of previously conducted studies on vaccine coverage and acceptability in Malawi, to determine the perceptions of healthcare workers on factors that will affect provision of the RTSS malaria vaccine in children between 12-23 months of age in Zomba, Malawi, and to determine the healthcare workers’ perception on factors that will affect uptake and acceptability of the 4-dose RTSS malaria vaccine in addition to routine vaccines for children aged 12-23 months in Zomba, Malawi. Methodology: Firstly, a systematic review will be conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework to identify research articles that address acceptability and coverage of vaccines in young children in Malawi. Secondly, a qualitative study design using purposive sampling of 20 healthcare workers at Zomba District Health Office will be conducted. Data will be collected using in depth telephonic interviews. Descriptive baseline statistics will be summarised using proportions. Qualitative data will be analysed using thematic content analysis to establish themes related to factors that affect coverage and acceptability of malaria RTSS vaccine. Expected findings and dissemination: The expected findings for this study are that the healthcare providers will describe the determinants of coverage and acceptance of the malaria RTSS vaccine to be similar to the other previously reported determinants of coverage and acceptance for vaccines in children aged 12 to 23 months in other studies conducted in Malawi. Study findings will be disseminated during the researcher’s Master of Vaccinology and Drug Development thesis defense at the University of Siena. Additionally, findings will be disseminated to COMREC and Zomba DHO. Finally, a manuscript will be developed which will be submitted for peer review journals for publication.