Maternal & Child Health

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Browsing Maternal & Child Health by Author "Chifisi, Rhoda"

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    Factors associated with mortality of premature babies with respiratory distress syndrome put on bubble continuous positive airway pressure at Kamuzu Central Hospital, Lilongwe-Malawi
    (Kamuzu University of Health Sciences, 2022-06-15) Chifisi, Rhoda
    Type of study: Retrospective cross-sectional study Background: Respiratory distress syndrome (RDS) is a breathing disorder that often occurs in babies that are born less than 37 gestational weeks (premature babies). It occurs as a result of immature lung development and the clinical features include cyanosis, fast breathing chest in drawings, and grunting respirations. One aspect of management of RDS includes the application of bubble continuous positive airway pressure (bCPAP) to expand the collapsed alveoli, thereby improving the work of breathing. Problem to be studied: The use of bCPAP has shown a decrease in morbidity and mortality for premature babies on global level, however, in Malawi a significant number still die despite receiving bCPAP. While studies have examined the factors associated with mortality of premature babies with RDS who receive bCPAP, few have been done in Malawi, and none have been conducted at Kamuzu Central Hospital, given it’s a new intervention. This study will add evidence to how bCPAP can be used effectively to prevent neonatal death. Broad objective of the study:  To determine maternal and neonatal factors associated with mortality of premature babies with RDS put on bCPAP between January 2019 to December 2021 at Kamuzu Central Hospital in Lilongwe, Malawi Specific objectives of the study:  To examine maternal factors associated with mortality of premature babies with RDS put on bCPAP between January 2019 to December 2021 at Kamuzu Central Hospital in Lilongwe, Malawi  To identify neonatal factors associated with mortality of premature babies with RDS put on bCPAP between January 2019 to December 2021 at Kamuzu Central Hospital in Lilongwe, Malawi Methodology: This study is a retrospective, cross sectional study conducted in the neonatal unit at Kamuzu Central Hospital (KCH) in Lilongwe, Malawi. This study will employ retrospective chart reviews of premature neonates to collect both maternal and neonatal factors that can be associated with mortality for premature babies receiving bCPAP. The study population are the premature neonates with RDS that were put on bCPAP at KCH neonatal unit between January 2019 and December 2021.The risk factors will be derived from careful review of the literature with consideration of the routine data collected during the neonate’s hospital stay. Data extraction sheet will be used for data collection. Data will be imported into Stata 16 software package andregression analysis will be performed to identify the statistically significant factors associated with mortality for this population. Expected findings and dissemination: Given the high rate of premature birth in Malawi, the results of this study have the potential to significantly impact neonatal outcomes This study addresses why premature neonates are still dying in Malawi, despite receiving bCPAP. Understanding of these factors will be used to inform changes that will help to improve outcomes of premature babies with respiratory distress syndrome put on bCPAP. The findings of this study will provide evidence to identify premature neonates on bCPAP who are at risk of dying and support a change in interventions to prevent neonatal death. Results will be disseminated to COMREC, KCH, CPAP project through Ministry of Health and an open access publication in a journal.